Basic information of OAS1 :
| Official Symbol of Gene | OAS1 |
| Species | Homo sapiens |
| Entrez Gene ID | 8086 |
| Official Full Name | 2'-5'-oligoadenylate synthetase 1 |
| Also known as | OIAS; IFI-4; OIASI; IMD100; E18/E16 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089127 MIM:164350; AllianceGenome:HGNC:8086 |
| Map Location | 12q24.13 |
| Variation Type | SNP |
| refSNP ID | rs3741981 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 333 MS cases and 424 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17092260 |
| Year | 2006 |
| Title | OAS1 gene haplotype confers susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Haplotype but not single-marker analysis revealed an association of the haplotype created by the G allele at rs 10774671 and the A allele at rs 3741981 with the susceptibility to MS |
| Mechanism/Pathway | OAS1 gene polymorphisms may confer susceptibility to MS or serve as markers of functional variants and suggest that OAS1 activity is involved in the etiology of the disease |
