Basic information of KIF1B :
| Official Symbol of Gene | KIF1B |
| Species | Homo sapiens |
| Entrez Gene ID | 16636 |
| Official Full Name | kinesin family member 1B |
| Also known as | KLP; CMT2; CMT2A; CMT2A1; HMSNII; NBLST1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000054523 MIM:605995; AllianceGenome:HGNC:16636 |
| Map Location | 1p36.22 |
| Variation Type | SNP |
| refSNP ID | rs10492972 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan PCR |
| Disease | MS |
| Disease subtype | PRMSã€PPMS |
| Population | N/A |
| Sample Size | 222 MS cases and 221 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20067515 |
| Year | 2010 |
| Title | Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | These results suggest that there is no effect in carrying the rs10492972 C variant on the risk of disease as well as on the rate of disability progression in a cohort of Italian patients with PPMS and patients with PRMS |
| Mechanism/Pathway | KIF1B gene represents the first non-inflammatory gene with a putative role on axonal loss and neurodegeneration found to be associated with multiple sclerosis |
