Basic information of HLA-G :
| Official Symbol of Gene | HLA-G |
| Species | Homo sapiens |
| Entrez Gene ID | 4964 |
| Official Full Name | major histocompatibility complex, class I, G |
| Also known as | MHC-G |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204632 MIM:142871; AllianceGenome:HGNC:4964 |
| Map Location | 6p22.1 |
| Variation Type | SNP |
| refSNP ID | —725C>G>T |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR and DNA sequencing |
| Disease | MS |
| Disease subtype | RRMSã€SPMS |
| Population | Polish population |
| Sample Size | 227 patients/288 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20636826 |
| Year | 2010 |
| Title | Association of the HLA-G gene polymorphism with multiple sclerosis in a Polish population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | ignificant differences were found only for the -725 promoter SNP. The -725C allele was significantly less frequent in the MS patients than in the controls, whereas the -725G allele was significantly more frequent in the MS patients than in the healthy subjects |
| Mechanism/Pathway | It is possible that the association of HLA-G with MS observed in our study is due to a strong linkage disequilibrium |
