Basic information of CXCL8 :
| Official Symbol of Gene | CXCL8 |
| Species | Homo sapiens |
| Entrez Gene ID | 3576 |
| Official Full Name | C-X-C motif chemokine ligand 8 |
| Also known as | IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; SCYB8 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000169429 MIM:146930; AllianceGenome:HGNC:6025 |
| Map Location | 4q13.3 |
| Variation Type | SNP |
| refSNP ID | rs2227306 |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 141MS |
Literature information of multiple sclerosis :
| Pubmed ID | 36803228 |
| Year | 2023 |
| Title | Genetic regulation of IL-8 influences disease presentation of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We describe for the first time a role of SNP rs2227306 of IL-8 gene in regulating the expression and the activity of this inflammatory cytokine in MS. |
| Mechanism/Pathway | The interleukin (IL)-8C>T rs2227306 single nucleotide polymorphism (SNP) regulates IL-8 activity in other clinical conditions; however, its role in MS has never been investigated. |
