Basic information of STAT4 :
| Official Symbol of Gene | STAT4 |
| Species | Homo sapiens |
| Entrez Gene ID | 6775 |
| Official Full Name | signal transducer and activator of transcription 4 |
| Also known as | SLEB11 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000138378 MIM:600558; AllianceGenome:HGNC:11365 |
| Map Location | 2q32.2-q32.3 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 40MS |
Literature information of multiple sclerosis :
| Pubmed ID | 29881250 |
| Year | 2018 |
| Title | STAT4 gene polymorphism in two major autoimmune diseases (multiple sclerosis and juvenile onset systemic lupus erythematosus) and its relation to disease severity |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | STAT4 polymorphism was significantly associated with MS and JO-SLE. Though homozygous JO-SLE patients are more risky for severe disease manifestations, homozygous MS patients are not risky for severe disease disability. |
| Mechanism/Pathway | Multiple sclerosis (MS) and systemic lupus erythematosus (SLE) are chronic autoimmune mediated diseases with strong genetic and environmental components. |
