Basic information of TNFRSF1A :
| Official Symbol of Gene | TNFRSF1A |
| Species | Homo sapiens |
| Entrez Gene ID | 7132 |
| Official Full Name | TNF receptor superfamily member 1A |
| Also known as | FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000067182 MIM:191190; AllianceGenome:HGNC:11916 |
| Map Location | 12p13.31 |
| Variation Type | SNP |
| refSNP ID | rs4149584 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 138MS |
Literature information of multiple sclerosis :
| Pubmed ID | 35963536 |
| Year | 2022 |
| Title | Variant rs4149584 (R92Q) of the TNFRSF1A gene in patients with familial multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Variant rs4149584 is associated with risk of developing MS. We analyzed its functional role in oligodendrocyte lineage cells and found an association with MS in homozygous carriers. |
| Mechanism/Pathway | Genomic studies have identified numerous genetic variants associated with susceptibility to multiple sclerosis (MS); however, each one explains only a small percentage of the risk of developing the disease. |
