Basic information of IL23A :
| Official Symbol of Gene | IL23A |
| Species | Homo sapiens |
| Entrez Gene ID | 51561 |
| Official Full Name | interleukin 23 subunit alpha |
| Also known as | P19; SGRF; IL-23; IL-23A; IL23P19 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000110944 MIM:605580; AllianceGenome:HGNC:15488 |
| Map Location | 12q13.3 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 157MS/95Control |
Literature information of multiple sclerosis :
| Pubmed ID | 35011777 |
| Year | 2021 |
| Title | Potential Contribution of IL-27 and IL-23 Gene Polymorphisms to Multiple Sclerosis Susceptibility: An Association Analysis at Genotype and Haplotype Level |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The results of the current study showed a significant relationship of IL-27-A964G and IL-27-T4730C polymorphisms with increased risk of MS, and also the protective role of the IL-23-R381Q polymorphism. Moreover, the haplotype-based analysis proposed the mutant G-C (A924G, T4730C) as a significant risk haplotype for the development of MS. |
| Mechanism/Pathway | Background: interleukin 23 (IL-23) and interleukin 27 (IL-27) modulate the activity of T helper 17 cells (Th17) with critical roles in autoimmune diseases and multiple sclerosis (MS). |
