Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | Alleles |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | NA |
| Disease | MS |
| Disease subtype | RRMS/SPMS/PPMS |
| Population | Sardinian descent. |
| Sample Size | 480 patients/340 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9311753 |
| Year | 1997 |
| Title | Multiple Sclerosis in Sardinia Is Associated and in Linkage Disequilibrium with HLA-DR3 and |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | However, the presence of different HLA class II allele associations, such as DRB1*1501 (DR2) in Caucasians (Hillert and Olerup 1993) and DRB1*040.. (DR4) and DRB1 *0301 (DR3), demonstrated both elsewhere (Marrosu et al. 1988) and in this report, suggests the possibility that any of these alleles may be the locus primarily involved in susceptibility to MS. |
| Mechanism/Pathway | The inheritance of MS appears to be complex and is believed to involve several genes |
