Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | Alleles |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS/PPMS |
| Population | white |
| Sample Size | 52 had relapsing-remitting, 32 secondary progressive, and 11 primary progressive types of the disease. |
Literature information of multiple sclerosis :
| Pubmed ID | 10406990 |
| Year | 1999 |
| Title | Association of the APOE ?4 allele with disease activity in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | ApoE ?4 patients (n=10) had a higher percent-age of partially recovered relapses (62%) as opposed to the non-?4 patients (n=26) who more commonly had completely rather than partially (42%) resolved relapses. |
| Mechanism/Pathway | Although APOE does not seem to be implicated in the early patho- genesis of the disease, patients possessing the ?4 allele might have a reduced capacity for neuronal remodelling after relapses. |
