Basic information of MPO :
| Official Symbol of Gene | MPO |
| Species | Homo sapiens |
| Entrez Gene ID | 4353 |
| Official Full Name | myeloperoxidase |
| Also known as | NA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000005381 MIM:606989; AllianceGenome:HGNC:7218 |
| Map Location | 17q22 |
| Variation Type | SNP |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS |
| Population | The majority of the MS patients were of Swedish origin, 2.7% originating from another Nordic country. (Finland, Norway or Denmark). |
| Sample Size | 871 patients/532 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17613595 |
| Year | 2007 |
| Title | An association study of two functional promotor polymorphisms in the myeloperoxidase (MPO) gene in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In this study, we investigated two polymorphisms located in the promotor region of the MPO gene, known to influence the expression of MPO, in a large case/control material consisting of 871 Swedish MS patients and 532 Swedish healthy controls. |
| Mechanism/Pathway | MPO is an enzyme found in myeloid cells which catalyses the production of hypochlorus acid, a potent microbicidal agent. It also plays an important role in inflammatory processes, where migrating neutrophiles may release active MPO and cause tissue damage. |
