Basic information of Mbp :
| Official Symbol of Gene | Mbp |
| Species | Homo sapiens |
| Entrez Gene ID | 4155 |
| Official Full Name | myelin basic protein |
| Also known as | NA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197971 MIM:159430; AllianceGenome:HGNC:6925 |
| Map Location | 18q23 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PCPMS |
| Population | Swedish |
| Sample Size | 149 patients/95controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9482678 |
| Year | 1998 |
| Title | The myelin basic protein gene in multiple sclerosis: identification of discrete alleles of a 1.3 kb tetranucleotide repeat sequence |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We conclude that the MBP gene does not influence susceptibility to MS in Swedish patients. |
| Mechanism/Pathway | Myelin basic protein (MBP) is a potential autoantigen in multiple sclerosis (MS) and its gene therefore is an attractive candidate to confer genetic susceptibility to this disease. Linkage and association with certain alleles of a 1.2 kb tetranucleotide repeat region 5' to the MBP gene with MS have been reported in Finnish patients, and an association has been reported from Denmark. |
