Basic information of CCL2 :
| Official Symbol of Gene | CCL2 |
| Species | Homo sapiens |
| Entrez Gene ID | 6347 |
| Official Full Name | C-C motif chemokine ligand 2 |
| Also known as | HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000108691 MIM:158105; AllianceGenome:HGNC:10618 |
| Map Location | 17q12 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | Peripheral blood mononuclear cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS/PPMS |
| Population | NA |
| Sample Size | 643patients/405controls |
Literature information of multiple sclerosis :
| Pubmed ID | 15191525 |
| Year | 2004 |
| Title | Analysis of the monocyte chemoattractant protein 1 -2518 promoter polymorphism in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Thus, our data could not reveal any association between the MCP-1 -2518 polymorphism and susceptibility to or clinical disease course of MS. |
| Mechanism/Pathway | Cytokines and chemokines like the proinflammatory chemokine, monocytechemoattractant protein 1 (MCP-1) are important for the recruitment of inflammatory cells into multiple sclerosis (MS) lesion |
