Basic information of VMP1 :
| Official Symbol of Gene | VMP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 81671 |
| Official Full Name | vacuole membrane protein 1 |
| Also known as | EPG3; TANGO5; TMEM49 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000062716 MIM:611753; AllianceGenome:HGNC:29559 |
| Map Location | 17q23.1 |
| Variation Type | SNP |
| refSNP ID | RS8070345 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS |
| Population | Sweden,Australia and Norway |
| Sample Size | 94MS |
Literature information of multiple sclerosis :
| Pubmed ID | 28766461 |
| Year | 2018 |
| Title | Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | VMP1/MIR21 methylation did not correlate with a known MS risk variant in VMP1 or smoking but displayed a significant negative correlation with age and the levels of mature miR-21 in CD4+ T cells |
| Mechanism/Pathway | Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by genetic and environmental factors. DNA methylation, an epigenetic mechanism that controls genome activity, may provide a link between genetic and environmental risk factors. |
