Basic information of BDNF :
| Official Symbol of Gene | BDNF |
| Species | Homo sapiens |
| Entrez Gene ID | 627 |
| Official Full Name | brain derived neurotrophic factor |
| Also known as | ANON2; BULN2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000176697 MIM:113505; AllianceGenome:HGNC:1033 |
| Map Location | 11p14.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 951 MS Family |
Literature information of multiple sclerosis :
| Pubmed ID | 16046000 |
| Year | 2005 |
| Title | The BDNF-Val66Met polymorphism: Implications for susceptibility to multiple sclerosis and severity of disease |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The BDNF-V al66Met-polymorphism leads to altered intracellular transport and secretion of BDNF, and is thus a logical candidate for a gene that influences susceptibility and, more specifically, the clinical course of multiple sclerosis. |
| Mechanism/Pathway | Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. |
