Basic information of CIITA :
| Official Symbol of Gene | CIITA |
| Species | Homo sapiens |
| Entrez Gene ID | 4261 |
| Official Full Name | class II major histocompatibility complex transactivator |
| Also known as | C2TA; NLRA; MHC2TA; CIITAIV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179583 MIM:600005; AllianceGenome:HGNC:7067 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs4774C |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Spanish |
| Sample Size | 149MS/562 control |
Literature information of multiple sclerosis :
| Pubmed ID | 19659749 |
| Year | 2010 |
| Title | MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | This study has verified previous results about the strong gene–envi-ronment interaction between HHV6A active replication and MHC2TA rs4774C.Furthermore, a different clinical behavior for MS patients with HHV-6A active infection and minor allele C was found. |
| Mechanism/Pathway | In a previous report, a strong gene–environment interaction between human herpesvirus 6A (HHV6A) active replication and MHC2TA rs4774C was demonstrated. |
