Basic information of HLA-B :
| Official Symbol of Gene | HLA-B |
| Species | Homo sapiens |
| Entrez Gene ID | 3106 |
| Official Full Name | major histocompatibility complex, class I, B |
| Also known as | AS; HLAB; B-4901 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000234745 MIM:142830; AllianceGenome:HGNC:4932 |
| Map Location | 6p21.33 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/ |
| Population | Norwegian |
| Sample Size | 631MS/555 control |
Literature information of multiple sclerosis :
| Pubmed ID | 19630074 |
| Year | 2009 |
| Title | Killer Immunoglobulin-like Receptor Ligand HLA-Bw4 Protects Against Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Carriage of the ligand of the inhibitory KIR3DL1 receptor, HLA-Bw4, was found to protect against MS in an HLA-DRB1 independent manner |
| Mechanism/Pathway | Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system. A human leukocyte antigen (HLA) class II association is well established (DRB1*1501-DQB1*0602), but more recently HLA class II–independent associations with HLA class I variants have also been reported. |
