Basic information of STAT3 :
| Official Symbol of Gene | STAT3 |
| Species | Homo sapiens |
| Entrez Gene ID | 6774 |
| Official Full Name | signal transducer and activator of transcription 3 |
| Also known as | APRF; HIES; ADMIO; ADMIO1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168610 MIM:102582; AllianceGenome:HGNC:11364 |
| Map Location | 17q21.2 |
| Variation Type | SNP |
| refSNP ID | rs744166 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | German Caucasian de-scent. |
| Sample Size | 2,932 MS cases and 2,972 control |
Literature information of multiple sclerosis :
| Pubmed ID | 22095036 |
| Year | 2012 |
| Title | Independent replication of STAT3 association with multiple sclerosis risk in a large German case–control sample |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio=1.09, P=0.012) in our sample |
| Mechanism/Pathway | Recent genome-wide association studies have implicated the “signal transducer and activator of transcription 3†gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. |
