Basic information of IL10 :
| Official Symbol of Gene | IL10 |
| Species | Homo sapiens |
| Entrez Gene ID | 3586 |
| Official Full Name | interleukin 10 |
| Also known as | CSIF; TGIF; GVHDS; IL-10; IL10A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962 |
| Map Location | 1q32.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 55MS/86Health |
Literature information of multiple sclerosis :
| Pubmed ID | 16183136 |
| Year | 2005 |
| Title | Pro- and anti-inflammatory cytokine gene polymorphism profiles in Bulgarian multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Although the size of the study group is small, these results indicate that polymorphic variations of two of the major anti-inflammatory cytokines, IL-10 and TGF-h, may play a role in MS susceptibility. |
| Mechanism/Pathway | Dysregulation in the expression of pro- and anti-inflammatory cytokines is one of the milestones in multiple sclerosis (MS) development and progression. The aim of this study was to investigate the possible influence of TNF-a (?308), TGF-h (codons 10 and 25), IL-10 (?1082, ?819, ?592), IL-6 (?174) and IFN-g (+ 874) polymorphisms on susceptibility to multiple sclerosis (MS). |
