Basic information of TYK2 :
| Official Symbol of Gene | TYK2 |
| Species | Homo sapiens |
| Entrez Gene ID | 7297 |
| Official Full Name | tyrosine kinase 2 |
| Also known as | JTK1; IMD35 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000105397 MIM:176941; AllianceGenome:HGNC:12440 |
| Map Location | 19p13.2 |
| Variation Type | SNP |
| refSNP ID | rs55762744 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | German ancestry |
| Sample Size | 4 MS Family |
Literature information of multiple sclerosis :
| Pubmed ID | 22744673 |
| Year | 2012 |
| Title | Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Within this pedigree, rs55762744 is common and appears to be a modifier of modest risk effect. |
| Mechanism/Pathway | To identify rare variants contributing to multiple sclerosis (MS) susceptibility in a family we have previously reported with up to 15 individuals affected across 4 generations. |
