Basic information of GALR2 :
| Official Symbol of Gene | GALR2 |
| Species | Homo sapiens |
| Entrez Gene ID | 8811 |
| Official Full Name | galanin receptor 2 |
| Also known as | GAL2-R; GALNR2; GALR-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000182687 MIM:603691; AllianceGenome:HGNC:4133 |
| Map Location | 17q25.1 |
| Variation Type | SNP |
| refSNP ID | rs61745847 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 1MS |
Literature information of multiple sclerosis :
| Pubmed ID | 30131588 |
| Year | 2018 |
| Title | A non-functional galanin receptor-2 in a multiple sclerosis patient |
Results of multiple sclerosis :
| Risk Type | up-regulation |
| Main Result | Phenotypic risk |
| Result | Here, after performing whole exome sequencing, we found a MS patient harboring a rare and homozygous single nucleotide variant (SNV; rs61745847) of the G-protein coupled receptor (GPCR) galanin-receptor 2 (GALR2) that alters an important amino acid in the TM6 molecular toggle switch region (W249L). |
| Mechanism/Pathway | Even though the etiology of MS remains unknown, it is accepted that it involves a combination of genetic alterations and environmental factors. |
