Basic information of IL-12 :
| Official Symbol of Gene | IL-12 |
| Species | Homo sapiens |
| Entrez Gene ID | 3593 |
| Official Full Name | interleukin 12B |
| Also known as | CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113302 MIM:161561; AllianceGenome:HGNC:5970 |
| Map Location | 5q33.3 |
| Variation Type | SNP |
| refSNP ID | rs3212227 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | Czech population. |
| Sample Size | 297MS/135Control |
Literature information of multiple sclerosis :
| Pubmed ID | 30069682 |
| Year | 2018 |
| Title | Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We also showed that IL-12B A1188C (rs3212227) can contribute to the progression of the disease in the Czech population. |
| Mechanism/Pathway | Pro-inflammatory and anti-inflammatory cytokines have been shown to play a crucial role in the pathophysiology of multiple sclerosis (MS) |
