Basic information of PPARGC1A :
| Official Symbol of Gene | PPARGC1A |
| Species | Homo sapiens |
| Entrez Gene ID | 10891 |
| Official Full Name | PPARG coactivator 1 alpha |
| Also known as | LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha) |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109819 MIM:604517; AllianceGenome:HGNC:9237 |
| Map Location | 4p15.2 |
| Variation Type | SNP |
| refSNP ID | rs8192678 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | Real-Time PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS |
| Population | Caucasian |
| Sample Size | 528MS/429Control |
Literature information of multiple sclerosis :
| Pubmed ID | 27105071 |
| Year | 2021 |
| Title | Association study of rs7799039, rs1137101 and rs8192678 gene variants with disease susceptibility/severity and corresponding LEP, LEPR and PGC1A gene expression in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our study implicates a significant role of LEP and LEPR polymorphisms and also leptin levels in the risk of MS and its severity. |
| Mechanism/Pathway | Leptin (LEP), leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma co- activator 1-alpha (PGC1A) are involved in the pathogenesis of multiple sclerosis (MS) by affecting the inflam-matory response and reactive oxygen species production. |
