Basic information of IL7 :
| Official Symbol of Gene | IL7 |
| Species | Homo sapiens |
| Entrez Gene ID | 3574 |
| Official Full Name | interleukin 7 |
| Also known as | IL-7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000104432 MIM:146660; AllianceGenome:HGNC:6023 |
| Map Location | 8q21.13 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 56MS/33Control |
Literature information of multiple sclerosis :
| Pubmed ID | 21287555 |
| Year | 2010 |
| Title | The interleukin-7 receptor a chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We found reduced IL-7Ra expression on conventional T cells and upregulated IL-7 plasma levels together with reduction of RTE-Treg frequencies and Treg function in MS, without clear genetic influence. Decreased IL-7Ra expression in MS correlated with declined dual-receptor-Treg and reduced MDC TSLPR expression, indicating contracted thymic Treg output |
| Mechanism/Pathway | RTE-Treg and long-lived memory Treg coincides with the MS-associated Treg defect, as shown previously. Recent studies demonstrate that IL-7 and thymic stromal lymphopoietin (TSLP) are critical for Treg matura-tion. |
