Basic information of IRF5 :
| Official Symbol of Gene | IRF5 |
| Species | Homo sapiens |
| Entrez Gene ID | 3663 |
| Official Full Name | interferon regulatory factor 5 |
| Also known as | SLEB10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000128604 MIM:607218; AllianceGenome:HGNC:6120 |
| Map Location | 7q32.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 145MS/300Control |
Literature information of multiple sclerosis :
| Pubmed ID | 26112714 |
| Year | 2015 |
| Title | Variants of Interferon Regulatory Factor 5 are Associated with Neither Neuromyelitis Optica Nor Multiple Sclerosis in the Southeastern Han Chinese Population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Our preliminary study indicates that genetic variants in IRF5 may affect neither NMO nor MS in the Southeastern Han Chinese population. Further studies with a large sample size and diverse ancestry populations are needed to clarify this issue. |
| Mechanism/Pathway | Neuromyelitis optica (NMO) and multiple sclerosis (MS) are demyelinating disorders of the central nervous system. Interferon regulatory factor 5 (IRF5) is a common susceptibility gene to different autoimmune disorders. However, the association of IRF5 variants with NMO and MS patients has not been well studied. Therefore, we aimed to evaluate whether IRF5 variants were associated with NMO and MS in the Southeastern Han Chinese population. |
