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Basic information of GFI1 :

Official Symbol of Gene GFI1
Species Homo sapiens
Entrez Gene ID 2672
Official Full Name growth factor independent 1 transcriptional repressor
Also known as SCN2; GFI-1; GFI1A; ZNF163
Gene Type protein coding
dbXrefs Ensembl:ENSG00000162676 MIM:600871; AllianceGenome:HGNC:4237
Map Location 1p22.1
Variation Type SNP
refSNP ID rs6680578

Sample information of multiple sclerosis:

Detected Sample peripheral blood
Sample Detail NA
Detected Method PCR
Disease MS
Disease subtype MS
Population NA
Sample Size 732MS/974Control

Literature information of multiple sclerosis :

Pubmed ID 20087403
Year 2010
Title Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis

Results of multiple sclerosis :

Risk Type Disease risk
Main Result Positive
Result This Tag-SNP captures two SNPs in complete linkage disequilibrium (r21), both located within the 17th intron of the EVI5 gene. Our findings agree with the corresponding data of the recent IMSGC study and present new genetic evidence that points to EVI5 as a factor of susceptibility to MS
Mechanism/Pathway We observed an association with MS in three of eight Tag-SNPs: rs11804321 (P0.008, OR1.29; 95% CI1.08–1.54), rs11808092 (P0.048, OR1.19; 95% CI1.03–1.39) and rs6680578 (P0.0082, OR1.23; 95% CI1.07–1.41)