Basic information of NFKB1 :
| Official Symbol of Gene | NFKB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4790 |
| Official Full Name | nuclear factor kappa B subunit 1 |
| Also known as | KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109320 MIM:164011; AllianceGenome:HGNC:7794 |
| Map Location | 4q24 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | NA |
| Sample Size | 800MS/400Control |
Literature information of multiple sclerosis :
| Pubmed ID | 12058256 |
| Year | 2002 |
| Title | Inhibitors in the NF?B cascade comprise prime candidate genes predisposing to multiple sclerosis,especially in selected combinations |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The genes of NF?B inhibitors exhibit more sequence variations. In the IKBL gene a predisposing allele was identified (13.1% vs 7.5% in the control group, P ? 0.001). |
| Mechanism/Pathway | Multiple sclerosis (MS) is an autoimmune disease displaying different clinical courses. In this multifactorial disease complex environmental as well as genetic predisposition factors contribute to the disease manifestation. |
