Basic information of CLEC16A :
| Official Symbol of Gene | CLEC16A |
| Species | Homo sapiens |
| Entrez Gene ID | 23274 |
| Official Full Name | C-type lectin domain containing 16A |
| Also known as | Gop-1; KIAA0350 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000038532 MIM:611303; AllianceGenome:HGNC:29013 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs6498169 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | Spanish population |
| Sample Size | 435MS/550Control |
Literature information of multiple sclerosis :
| Pubmed ID | 19221398 |
| Year | 2010 |
| Title | Chromosomal region 16p13: further evidence of increased predisposition to immune diseases |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Associations of CLEC16A polymorphisms with T1D and MS were successfully replicated in a Spanish population. A novel association of rs6498169 with a predisposition to RA was described which is consistent with previous MHC2TA results. These data provide evidence for the influence of variants within this chromosomal region on the development of complex diseases. |
| Mechanism/Pathway | Genome-wide studies have identified the chromosomal region 16p13 in the susceptibility to type 1 diabetes (T1D) and multiple sclerosis (MS). |
