Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 116MS |
Literature information of multiple sclerosis :
| Pubmed ID | 7759306 |
| Year | 1995 |
| Title | TAP2 Gene Polymorphism Contributes to Genetic Susceptibility to Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The J genetic variability and are involved in the transport of mutation was not found in linkage disequilibrium with antigenic peptides from the cytoplasm to the endoplasmic the HLA-DRB lx 150 1 allele and can be considered an reticulum. Comparison of 116 MS patients with Cauca- additional genetic susceptibility marker of the disease. |
| Mechanism/Pathway | MS is an autoimmune demyelinating dis- between the previously described alleles of the TAP1 and ease that has been known to be associated with the HLA- TAP2 genes and MS. We report here an additional TAP2 DRB1*1501-DQA1*0102-DQB1~0602 haplotype. |
