Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 374MS |
Literature information of multiple sclerosis :
| Pubmed ID | 11552016 |
| Year | 2001 |
| Title | Apolipoprotein E ?4 is associated with rapid progression of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | These results suggest no effect of the APOE genotype on susceptibility to MS, but indicate an association of the APOE ?4 allele with a more severe course of the disease. |
| Mechanism/Pathway | Apolipoprotein E (apoE) influences the high-affinity binding of low-density lipoproteins (LDL) to their receptor. |
