Basic information of TGFB1 :
| Official Symbol of Gene | TGFB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 7040 |
| Official Full Name | transforming growth factor beta 1 |
| Also known as | CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000105329 MIM:190180; AllianceGenome:HGNC:11766 |
| Map Location | 19q13.2 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Bulgarian patients. |
| Sample Size | 183MS/307Control |
Literature information of multiple sclerosis :
| Pubmed ID | 33480235 |
| Year | 2020 |
| Title | A link between promoter polymorphisms of the transforming growth factor β1 (TGFB1) and TGF-β1 receptor II (TGFBR2) genes and relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In summary, we suggest that in males, a higher TGF-β1 level determined by TGFB1T[-509]T genotype in combination with the TGFBR2G[-875]A genotype might be a protective factor against RRMS development. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a chronic progressive autoimmune disease characterised by nerve demye-lination, mediated by myelin-specific Th1 autoreactive cells. |
