Basic information of CTLA-4 :
| Official Symbol of Gene | CTLA-4 |
| Species | Homo sapiens |
| Entrez Gene ID | 1493 |
| Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
| Also known as | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505 |
| Map Location | 2q33.2 |
| Variation Type | SNP |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR/TaqMan Assay/multiplex SNaPshot assay |
| Disease | MS |
| Disease subtype | All patients satisfied the Poser criteria for definite (95%), or probable (5%) multiple sclerosis; 60% had relapsing, 31% secondary progressive and 9% primary progressive multiple sclerosis. |
| Population | NA |
| Sample Size | 771 patients |
Literature information of multiple sclerosis :
| Pubmed ID | 16325273 |
| Year | 2016 |
| Title | No evidence of a significant role for CTLA-4 in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | No individual marker or common haplotype showed evidence of association with disease. These data suggest that any effect of CTLA-4 on multiple sclerosis susceptibility is likely to be very small. |
| Mechanism/Pathway | V ariation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. |
