Basic information of CXCL10 :
| Official Symbol of Gene | CXCL10 |
| Species | Homo sapiens |
| Entrez Gene ID | 3627 |
| Official Full Name | C-X-C motif chemokine ligand 10 |
| Also known as | C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000169245 MIM:147310; AllianceGenome:HGNC:10637 |
| Map Location | 4q21.1 |
| Variation Type | SNP |
| refSNP ID | rs8878 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | Taqman methodology |
| Disease | MS |
| Disease subtype | RRMS/SPMS/PPMS |
| Population | Caucasians originating from a limited area in Northern Italy. |
| Sample Size | 226 patients/235 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17250724 |
| Year | 2007 |
| Title | CXCL10 haplotypes and multiple sclerosis: association and correlation with clinical course |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Positive |
| Result | but is probably to influence the course of MS, possibly contributing to slow down the progression of the disease. |
| Mechanism/Pathway | CXCL10 (interferon-c-inducible protein-10) levels are increased in cerebrospinal fluid of multiple sclerosis (MS) patients with symptomatic attacks of inflammatory demyelination, supporting a role for this molecule in MS pathogenesis |
