Basic information of CCL7 :
| Official Symbol of Gene | CCL7 |
| Species | Homo sapiens |
| Entrez Gene ID | 6354 |
| Official Full Name | C-C motif chemokine ligand 7 |
| Also known as | FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000108688 MIM:158106; AllianceGenome:HGNC:10634 |
| Map Location | 17q12 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR-SSP |
| Disease | MS |
| Disease subtype | NA |
| Population | Swedish |
| Sample Size | 192 patients/129 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 10229131 |
| Year | 1999 |
| Title | Microsatellite polymorphisms in the gene promoter of monocyte chemotactic protein-3 and analysis of the association between monocyte chemotactic protein-3 alleles and multiple sclerosis development |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We conclude that the MCP-3)A4 allele might protect against MS development on the background of the increased risk in HLA-DRB1)15q individuals and the MCP-3)A2 allele seems protective in low-risk individuals, who are both negative for DRB1)03 and DRB1)15. |
| Mechanism/Pathway | Monocyte chemotactic protein 3 MCP-3 is a chemokine that attracts mononuclear cells, including monocytes and lymphocytes, the inflammatory cell types that predominate in multiple sclerosis lesions. |
