Basic information of HLA-DMB :
| Official Symbol of Gene | HLA-DMB |
| Species | Homo sapiens |
| Entrez Gene ID | 3109 |
| Official Full Name | major histocompatibility complex, class II, DM beta |
| Also known as | RING7; D6S221E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242574 MIM:142856; AllianceGenome:HGNC:4935 |
| Map Location | 6p21.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS/ |
| Population | NA |
| Sample Size | 63 patients/46 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9258248 |
| Year | 1997 |
| Title | HLA-DM polymorphisms do not associate with multiple sclerosis: an association study with analysis of myelin basic protein T cell specificity |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Patients with predominant responses to different MBP epitopes did not differ for their HLA-DM haplotype while patients with predominant responses to the same MBP epitope could present different HLA-DM haplotypes. HLA-DM polymorphisms do not associate with MS and may not affect specific patterns of T cell responses to MBP |
| Mechanism/Pathway | The MHC region on 6p harbors at least one susceptibility gene for multiple sclerosis MS . Within this region, HLA-DM loci are of interest being involved in class II antigen processing. |
