Basic information of IL2 :
| Official Symbol of Gene | IL2 |
| Species | Homo sapiens |
| Entrez Gene ID | 3558 |
| Official Full Name | interleukin 2 |
| Also known as | IL-2; TCGF; lymphokine |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109471 MIM:147680; AllianceGenome:HGNC:6001 |
| Map Location | 4q27 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS/ |
| Population | Caucasians from Granada and Malaga, Spain. |
| Sample Size | 173 patients/153controls |
Literature information of multiple sclerosis :
| Pubmed ID | 11525806 |
| Year | 2001 |
| Title | Allelic expression and interleukin-2 polymorphisms in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | These data indicate for the first time the relevance of the il-2 gene locus in human MS and its possible involvement in other autoimmune diseases |
| Mechanism/Pathway | We have investigated the association of two single nucleotide polymorphisms SNPs at positions y384 and 114 in the human interleukin-2 hIL-2 with multiple sclerosis MS . For two of the y384 genotypes GrT, TrT , we observed an association with the susceptibility to secondary progressive SP course of MS Ps0.005 and Ps0.013, respectively |
