Basic information of TNF :

Official Symbol of Gene	TNF
Species	Homo sapiens
Entrez Gene ID	7124
Official Full Name	tumor necrosis factor
Also known as	DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892
Map Location	6p21.33
Variation Type	Allele
refSNP ID	NA

Sample information of multiple sclerosis:

Detected Sample	CSF/peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	RRMS/PPMS/SPMS
Population	N/A
Sample Size	50 MS/22Health

Literature information of multiple sclerosis :

Pubmed ID	8887999
Year	1996
Title	Gene polymorphism at position -308 of the tumor-necrosis-factor- (TNF-c ) in Multiple Sclerosis and it's influence on the regulation of TNF-c production

Results of multiple sclerosis :

Risk Type	Phenotypic risk
Main Result	Positive
Result	Considering the association of different TNF-~ alleles with diverse autoimmune diseases we sequenced the TNF-u promotor region (-674 to +201) of 23 patients with relapsing/remitting MS, of 27 patients with chronic progressive MS (21 patients had primary progressive course and six patients had a secondary progressive course) and of 22 healthy controls, who had no history of MS in their families. In three of 21 patients (14%) with primary chronic progressive MS a homozygous point-mutation at position -308 could be demonstrated where guanine (G) was substituted by adenosine (A). This mutation could neither be detected in patients with relapsing/ remitting MS nor in healthy controls. However, 40% of the patients with relapsing/remitting MS and 43% of the primary chronic progressive MS patients were heterozygous at position -308 for G/A, whereas only 32% of healthy controls showed this heterogeneity.
Mechanism/Pathway	Tumor-necrosis-factor-~ (TNF-c0 is a major mediator of the inflammatory immune response and may play an important role in the pathogenesis and progression of Multiple Sclerosis (MS).