Basic information of TRB :
| Official Symbol of Gene | TRB |
| Species | Homo sapiens |
| Entrez Gene ID | 6957 |
| Official Full Name | T cell receptor beta locus |
| Also known as | TCRB; TRB@ |
| Gene Type | protein coding |
| dbXrefs | AllianceGenome:HGNC:12155 |
| Map Location | 7q34 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/RPMS/ |
| Population | Caucasian from British Columbia |
| Sample Size | 14 DRw15+/12DRw15- |
Literature information of multiple sclerosis :
| Pubmed ID | 9463308 |
| Year | 1998 |
| Title | Susceptibility to relapsing-progressive multiple sclerosis is associated with inheritance of genes linked to the variable region of the TcR beta locus: use of affected family-based controls |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | Susceptibility to RP MS is associated both with a recessive inheritance of a gene linked to the 30 (Vb11) end of the 2-1 subhaplotype defined by the Vb8-BamHI and Vb11-BamHI alleles in DRw151 patients and with a gene, located on the 1-1 subhaplotype, defined by the Vb1-TaqI and Vb8-MspI alleles of the TcR b-chain com-plex in DRw152 patients. |
| Mechanism/Pathway | We tested the hypothesis that susceptibility to relapsing-progressive (RP) (but not to relapsing-remitting [RR])multiple sclerosis (MS) is associated with a gene linked to the TcR b-chain variable region delimited by the Vb8-BamHI and Vb11-BamHI RFLP alleles in DRw151 MS patients, using a contingency-table test of patient data and affected family–based controls. |
