Basic information of NOD2 :
| Official Symbol of Gene | NOD2 |
| Species | Homo sapiens |
| Entrez Gene ID | 64127 |
| Official Full Name | nucleotide binding oligomerization domain containing 2 |
| Also known as | CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000167207 MIM:605956; AllianceGenome:HGNC:5331 |
| Map Location | 16q12.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | N/A |
| Sample Size | 631 MS/342Health |
Literature information of multiple sclerosis :
| Pubmed ID | 12876263 |
| Year | 2003 |
| Title | Crohn’s associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Our results indicate that the NOD2 gene is probably not influencing susceptibility to autoimmune disease in general but is specific for Crohn’s disease. |
| Mechanism/Pathway | During the last few years striking progress has been made in unravelling the genetic basis of susceptibility to Crohn’s disease. Significant evidence for linkage in the pericentromericc region of chromosome 16 has been found,3 fol-lowing on from which two independent groups, one using association mapping4 and the other following a candidate gene approach,5 identified the relevant gene as NOD2. |
