Basic information of GRM7 :
| Official Symbol of Gene | GRM7 |
| Species | Homo sapiens |
| Entrez Gene ID | 2917 |
| Official Full Name | glutamate metabotropic receptor 7 |
| Also known as | GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196277 MIM:604101; AllianceGenome:HGNC:4599 |
| Map Location | 3p26.1 |
| Variation Type | SNP |
| refSNP ID | rs779867 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | West of Iran. |
| Sample Size | 397MS/400Health |
Literature information of multiple sclerosis :
| Pubmed ID | 30616226 |
| Year | 2019 |
| Title | A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The rs779867 was associated with MS risk in recessive model (OR (95% CI) = 0.67 (0.48–0.94)), P-value = 0.02, adjusted P-value = 0.04). |
| Mechanism/Pathway | Glutamate excitotoxicity has been previously associated with development of multiple sclerosis (MS). The me-tabotropic glutamate receptor 7 (GRM7) gene is a G protein-coupled receptor that suppresses the cyclic AMP cascade after activation by glutamate. |
