Basic information of LTA :
| Official Symbol of Gene | LTA |
| Species | Homo sapiens |
| Entrez Gene ID | 4049 |
| Official Full Name | lymphotoxin alpha |
| Also known as | LT; TNFB; TNFSF1; TNLG1E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000226979 MIM:153440; AllianceGenome:HGNC:6709 |
| Map Location | 6p21.33 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Caucasians from Hordaland county, western Norway. |
| Sample Size | 133MS/148Health |
Literature information of multiple sclerosis :
| Pubmed ID | 12568117 |
| Year | 2002 |
| Title | TNF-a and -b Gene Polymorphisms in Multiple Sclerosis: A Highly Significant Role for Determinants in the First Intron of the TNF-b Gene |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | These results suggest that the TNF-b gene plays a significant role in the etiopathogenesis of MS. |
| Mechanism/Pathway | Tumor necrosis factor (TNF)-a and TNF-b are proinflammatory cytokines that have been implicated in the pathogenesis of several autoimmune diseases |
