Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Caucasians from Hordaland county, western Norway. |
| Sample Size | 133MS/148Health |
Literature information of multiple sclerosis :
| Pubmed ID | 12568117 |
| Year | 2002 |
| Title | TNF-a and -b Gene Polymorphisms in Multiple Sclerosis: A Highly Significant Role for Determinants in the First Intron of the TNF-b Gene |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | TNF-α genotypes were not associated with MS |
| Mechanism/Pathway | Tumor necrosis factor (TNF)-a and TNF-b are proinflammatory cytokines that have been implicated in the pathogenesis of several autoimmune diseases |
