Basic information of CD226 :
| Official Symbol of Gene | CD226 |
| Species | Homo sapiens |
| Entrez Gene ID | 10666 |
| Official Full Name | CD226 molecule |
| Also known as | PTA1; DNAM1; DNAM-1; TLiSA1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000150637 MIM:605397; AllianceGenome:HGNC:16961 |
| Map Location | 18q22.2 |
| Variation Type | SNP |
| refSNP ID | rs763361 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | NA |
| Sample Size | 2187MS/9972Health |
Literature information of multiple sclerosis :
| Pubmed ID | 18971939 |
| Year | 2009 |
| Title | CD226 Gly307Ser association with multiple autoimmune diseases |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The Ser307 allele of rs763361 in exon 7 of CD226 predisposes to T1D,MS, possibly AITD and possibly RA, and based on the tag SNP analysis, could be the causal variant. |
| Mechanism/Pathway | We previously reported association of a nonsynonymous single nucleotide polymorphism (nsSNP) rs763361/Gly307Ser in the immune response gene CD226 on chromosome 18q22 with type 1 diabetes (T1D) susceptibility. |
