Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | amino acid polymorphisms |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Japanese |
| Sample Size | 45MS/429Health |
Literature information of multiple sclerosis :
| Pubmed ID | 31382992 |
| Year | 2019 |
| Title | Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | HLA-B*39:01, and HLA-B*15:01 as being associated with independent MS susceptibility |
| Mechanism/Pathway | In auto-immune diseases, such as rheumatoid arthritis, psoriasis, and type 1 diabetes, fine-mapping studies have identified strong genetic risk variants in the MHC region |
