Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | rs703842 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Slovaks |
| Sample Size | 496MS/521Health |
Literature information of multiple sclerosis :
| Pubmed ID | 30875612 |
| Year | 2019 |
| Title | The association of rs703842 variants in CYP27B1 with multiple sclerosis susceptibility is influenced by the HLA-DRB1*15:01 allele in Slovaks |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | For the first time in Central European Slovak population, we found the rs703842 allele C to be protective factor against MS development |
| Mechanism/Pathway | In addition, the study of Simon et al. (2011) showed that the association of rs703842 with MS risk could be dependent on the pre-sence of Human Leucocyte Antigen (HLA) DRB1*15:01 allele, that is known to be one of the most important genetic MS susceptibility factors |
