Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Caucasian |
| Sample Size | 176MS/1761Health |
Literature information of multiple sclerosis :
| Pubmed ID | 12825072 |
| Year | 2003 |
| Title | Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-a gene and their associations with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result |
There were trends towards an increase of the GTG+ haplotype (odds ratio |
| Mechanism/Pathway | We have investigated the interleukin-7 receptor (IL-7R) a-chain gene as a positional and functional candidate gene for susceptibility to multiple sclerosis (MS), in view of its chromosomal location on 5p14–p12, a region that has shown suggestive linkage in MS genome screens, and its role in T- and B-cell proliferation and reactivity. |
