Basic information of IGH :
| Official Symbol of Gene | IGH |
| Species | Homo sapiens |
| Entrez Gene ID | 3492 |
| Official Full Name | immunoglobulin heavy locus |
| Also known as | IGD1; IGH@; IGHJ; IGHV; IGHD@; IGHJ@; IGHV@; IGH.1@; IGHDY1 |
| Gene Type | protein coding |
| dbXrefs | MIM:146910; MIM:147010; MIM:147070; AllianceGenome:HGNC:5477 |
| Map Location | 14q32.33 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Swedish |
| Sample Size | 113MS/781Health |
Literature information of multiple sclerosis :
| Pubmed ID | 9306094 |
| Year | 1997 |
| Title | NO LINKAGE OR ASSOCIATION OF A VNTR MARKER IN THE JUNCTION REGION OF THE IMMUNOGLOBULIN HEAVY CHAIN GENES IN MULTIPLE SCLEROSIS |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We conclude that the IgH chain genes are unlikely to playa role in genetic susceptibility to MS in the Swedish population. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system. Autoantibodies are thought to participate in the pathogenesis. Previous reports on the role of immunoglobulin (Ig) variable gene segments in MS are contradictory. |
