Basic information of HLA-DQA1 :
| Official Symbol of Gene | HLA-DQA1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3117 |
| Official Full Name | major histocompatibility complex, class II, DQ alpha 1 |
| Also known as | DQA1; DQ-A1; CELIAC1; HLA-DQA; HLA-DQB1; HLA-DQA1* |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196735 MIM:146880; AllianceGenome:HGNC:4942 |
| Map Location | 6p21.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | NA |
| Sample Size | 95MS |
Literature information of multiple sclerosis :
| Pubmed ID | 34877984 |
| Year | 2020 |
| Title | HLA-DQA1*04:01 is related to a higher multiple sclerosis lesion load on T2/Flair MRI sequences |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The correlation of the HLA-DQA1*04:01 allele with a higher lesion load on T2/Flair MRI sequences suggests that the presence of this allele is associated with the risk of greater MS severity. |
| Mechanism/Pathway | The genetic predisposition to multiple sclerosis (MS) is associated with HLA alleles, especially HLA-DRB1*15:01. |
