Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | NA |
| Sample Size | 385MS/361Health |
Literature information of multiple sclerosis :
| Pubmed ID | 16193886 |
| Year | 2005 |
| Title | Apo E in multiple sclerosis and optic neuritis: the Apo E-o4 allele is associated with progression of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | Apo E genotypes do not influence the development of MS and ON. The Apo o4 allele seems to predispose carriers with MS to a faster progression of diseas |
| Mechanism/Pathway | T o investigate the association between apolipoprotein E (Apo E) genotype in multiple sclerosis (MS) and acute monosymptomatic optic neuritis (ON) in a genetically homogeneous population with a high frequency of the Apoo4 allele. |
