Basic information of PTPRC :
| Official Symbol of Gene | PTPRC |
| Species | Homo sapiens |
| Entrez Gene ID | 5788 |
| Official Full Name | protein tyrosine phosphatase receptor type C |
| Also known as | LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000081237 MIM:151460; AllianceGenome:HGNC:9666 |
| Map Location | 1q31.3-q32.1 |
| Variation Type | SNP |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/ |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 15584483 |
| Year | 2004 |
| Title | CD45 (PTPRC) as a candidate gene in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We conclude that the 77C0/G PTPRC polymorphism is present and preferentially transmitted in a small subgroup (B/5%) of MS families,which may only be detected with complementary methods of analysis |
| Mechanism/Pathway | The 77C0/G polymorphism in exon 4 of CD45 or protein tyrosine phosphatase receptor-type C (PTPRC) has been investigated in families with multiple sclerosis (MS) and in several cohorts of sporadic patients and controls, however, with conflicting results. |
