Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | amino acid polymorphisms |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | Lithuanian population. |
| Sample Size | 80MS |
Literature information of multiple sclerosis :
| Pubmed ID | 22112985 |
| Year | 2011 |
| Title | The Significance of HLA DRB1*1501 and Oligoclonal Bands in Multiple Sclerosis: Clinical Features and Disability |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | There were no significant associations between the presence of HLA DRB1*1501 allele and the clinical symptoms, course of disease, or disability score. |
| Mechanism/Pathway | A great vari-ety of recently reported linkage and genome-wide association studies have established that the most important genetic risk factor in MS is carriage of a single copy of the HLA class II allele DRB1*15 to homozygote forms (6–8). About 60% of MS patients in Northern Europe are positive for HLA-DRB1*15, compared with 30% of healthy controls |
